The burden of endocrine-disrupting chemicals in the USA
نویسندگان
چکیده
منابع مشابه
Endocrine disrupting chemicals
The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...
متن کاملThe challenge posed by endocrine-disrupting chemicals.
Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literature. A list of priorities is provided, including the need for additional epidemiological and wildlife studies, the derivation of a coordinated testing strategy, agreement on the toxicities expected o...
متن کاملCryptorchidism and endocrine disrupting chemicals
Prospective clinical studies have suggested that the rate of congenital cryptorchidism has increased since the 1950s. It has been hypothesized that this may be related to environmental factors. Testicular descent occurs in two phases controlled by Leydig cell-derived hormones insulin-like peptide 3 (INSL3) and testosterone. Disorders in fetal androgen production/action or suppression of Insl3 a...
متن کاملRole of endocrine disrupting chemicals on the tissue levels of AhR and sex steroid receptors in breast tumours
Breast cancer affects Iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in Tehran. Thisstudy aimed to compare the AhR levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. Possible associations of AhR with lifestyle and reproductive risk factorsand ...
متن کاملEstimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European union.
CONTEXT Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability. OBJECTIVE The objective was to quantify a range of health and economic costs that can be reasonably attributed to EDC exposures in the European Union (EU). DESIGN A Steering Committee of scientists adapted the Intergovernmental Panel on Climate Ch...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2016
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2016.198